By Robert Lev
Adenomatous Polyps of the Colon: Pathobiological and Clinical Features consolidates the mammoth physique of easy technology and medical info linked to adenomatous polyps of the colon, a lot of it encouraged via the belief that almost all colorectal carcinomas appear to come up in such polyps. This e-book strives to judge those information, with specific emphasis on their implications for administration of polyp-bearing matters. subject matters comprehensively explored contain anatomy and histology of the conventional colon; pathologic features of adenomatous polyps, differential prognosis, and grading schemes for measure of dysplasia and villosity; adenomatous polyposes; histologic and epidemiologic proof for the malignant power of adenomatous polyps; and detection and administration, with particular recognition to endoscopy, endoscopic polypectomy, the malignant polyp, and post-polypectomy surveillance schedules.
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Extra resources for Adenomatous Polyps of the Colon: Pathobiological and Clinical Features
1987) felt that plasmin generated from plasminogen activator could playa role in conversion of AP into carcinoma by digesting the epithelial basement membranes of polyps. Forster et aI. (1986) have noted a loss in laminin from the basement membrane in some rectal carcinomas, a feature associated with a poorer prognosis. Malignant glands invading the lamina propria or submucosa generally invoke a fibroblastic response not found with in 36 2. Pathology situ carcinomas confined by a basement membrane.
For example, there is a predominance of sulfomucin over sialomucin in adenomatous epithelium, which is similar to the sulfomucin predominance in normal deep crypts. , 1987). , 1988). Of course, histochemical similarities do not necessarily reflect common ancestry, but the evidence is supportive of such a relationship. Oohara et ai. (1982) also suggested that adenomas arose from basal cells in deep crypts. They stated that 100 percent of APs in nonpolyposis cases and 82 percent of APs in familial polyposis arose in that fashion.
Elias H, Hyde DM, Mullens RS, Lambert FC (1981) Colonic adenomas: Stereologyand growth mechanisms. Dis Colon Rectum 24:331-342. Enterline HT (1976) Polyps and cancer of the large bowel. In B Morson (ed): Current Topics in Pathology: Vul 63. Pathology of the Gastrointestinal Tract. Springer-Verlag, Berlin, pp 95-141. Enterline HT, Arvan DA (1967) Chromosome constitution of adenoma and adenocarcinoma of the colon. Cancer 20:1746-1759. Estrada R, Spjut H (1980) Hyperplastic polyps of the large bowel.