By Philip N Patsalos
This up to date 3rd variation of a profitable publication is an outline of either pharmacokinetic and pharmacodynamic antiepileptic drug (AED) interactions, together with info of the significance and mechanism of interactions, and in addition of drug combos that aren't linked to interactions and for this reason might be coprescribed with out undue drawback. offered in alphabetical order and by means of drug classification, drug interactions that take place among AEDs and in addition among AEDs and non-AEDs are defined in 3 sections: Drug interactions among AEDs; Drug interactions among AEDs and non-AED medicines: Interactions affecting AEDs; Drug interactions among AEDs and non-AED medicines: Interactions stricken by AEDs.
Antiepileptic Drug Interactions: A medical advisor, third Edition with its transparent, concise and unambiguous content material will
allow physicians and allied wellbeing and fitness execs to make extra rational offerings whilst AED polytherapy regimens are indicated. there's constantly a decision and averting hugely interacting medicinal drugs and selecting drug combos which are minimally interacting or don't have interaction could be the aim in treating sufferers with epilepsy. This ebook presents all of the invaluable info with a purpose to permit this aim to be accomplished and, if valuable, to assist potent administration of AED interactions.
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Additional resources for Antiepileptic Drug Interactions: A Clinical Guide
NA NA ESM↑↓ NA ? NA ESM⇓ NA NA ESM↑ NA ? FBM↑ ↔ ? NA ? NA NA ? NA NA ↔ NA NA ↔ NA NA NA NA NA ↔ ↔ NA NA NA ? NA NA NA ↔ ↔ LTG⇑ ↔ ↔ ↔ LTG⇓ LTG↓ LTG↓ ? ↔ ↔ ↔ ↔ NA ↔ ↔ NA NA NA BRV brivaracetam, CBZ carbamazepine, CBZ-E carbamazepine-10,11-epoxide (active metabolite of CBZ), CLB clobazam, CZP clonazepam, DMCLB N-desmethylclobazam (active metabolite of CLB), ESL-a eslicarbazepine acetate, ESL eslicarbazepine (active metabolite of ESL-a), ESM ethosuximide, FBM felbamate, GBP gabapentin, H-OXC 10-hydroxy-carbazepine (active metabolite of OXC), LCM lacosamide, LEV levetiracetam, LTG lamotrigine, OXC oxcarbazepine, PMP perampanel, PB phenobarbital, PHT phenytoin, PGB pregabalin, PRM primidone, RTG retigabine, RFN rufinamide, STP stiripentol, TGB tiagabine, TPM topiramate, VPA valproic acid, VGB vigabatrin, ZNS zonisamide NA ?
NA NA ? NA ? NA NA RTG↑ NA ? NA RTG↑ RTG↓ NA RFN↓ NA — ? ↔ NA NA NA ? ↔ NA ↔ NA RFN↓ NA RFN↓ RFN↓ RFN NA RFN↓ NA STP⇓ NA NA — STP↑ NA NA NA ? NA NA NA NA ? NA STP⇓ STP⇓ STP NA STP⇓ TGB↓ TGB⇓ NA NA ? ? NA NA ? NA NA NA NA ? NA TGB⇓ TGB⇓ TGB NA TGB⇓ ↔ TPM⇓ ↔ ↔ ? NA TPM↓ NA ? ↔ ↔ ↔ ↔ TPM↓ ↔ TPM⇓ TPM⇓ TPM ↔ TPM⇓ ↔ VPA⇓ ↔ ↔ VPA⇑ VPA↑ ↔ VPA↓ VPA↓ VPA⇑ ↔ ↔ VPA↓ ↔ ↔ VPA↓ VPA⇓ VPA⇓ VPA ↔ VPA⇓ NA ↔ NA NA NA NA NA NA NA VGB↓ NA NA NA ↔ NA NA ↔ ↔ VGB NA ↔ NA ZNS⇓ NA NA ? NA ↔ NA NA ? NA ↔ ↔ NA NA ↔ ZNS⇓ ZNS⇓ ZNS ↔ ZNS⇓ 4 Part I Drug Interactions Between AEDs ?
1992;14:165–74. 34. Miller RR, Porter J, Greenblatt DJ. Clinical importance of the interaction of phenytoin and isoniazid. Chest. 1979;75:356–8. 35. Garg SK, Kumar N, Bhargava VK, Prabhakar SK. Effect of grapefruit juice on carbamazepine bioavailability in patients with epilepsy. Clin Pharmacol Ther. 1998;64:286–8. 36. Johannessen Landmark C, Patsalos PN. Methodologies used to identify and characterise interactions among antiepileptic drugs. Exp Rev Clin Pharmacol. 2012;5:281–92. 37. Johannessen SI, Bettino D, Berry DJ, Bialer M, Kramer G, Tomson T, Patsalos PN.