Download Atom: An Odyssey from the Big Bang to Life on Earth...and by Lawrence M. Krauss PDF

By Lawrence M. Krauss

Each atom in bodies was contained in the fiery middle of a celebrity that exploded billions of years ahead of our sunlight approach was once shaped. just like the unique Homeric epic, the atom on the heart of this publication makes its approach throughout a very cosmic level. Exploding supernovas, sun winds, collapsing stars preceded the increase of existence in the world and someday might foretell its finish. but the tale that Krauss tells is inextricably our tale. all through this staggering and enormous paintings, he manages to stoke our ask yourself on the powers and not going occasions that conspired to create our sun method, our eco-system and us.

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Paclitaxel (Taxol) docetaxel (Taxotere) The NCI commenced the Phase I clinical trials of taxol in 1984 and Phase II trials in 1987 with positive results. S. pharmaceutical company to have made a bid, was awarded the molecule. BMS successfully carried out the Phase III trials for taxol. The FDA approved taxol for use in refractory ovarian cancer in 1992, for breast cancer in 1994, and later for non-small-cell lung cancer and Kaposi's sarcoma. Meanwhile, French company RhonePoulenc marketed a competing drug docetaxel (Taxotere), discovered by French chemist Pierre Potier, who invented docetaxel by a minor modification of taxol (replacing the benzyl amide group on taxol with a ter/-butoxyl-carbamate group).

Recent studies have shown that the risks of drug-drug interactions increase 1400 times if statins are combined with fibrates. 1). AstraZeneca licensed rosuvastatin (Crestor), the seventh statin on the market, from Japanese company Shionogi & Co. Ltd. 50 In 2003, the FDA approved Crestor in 5-40mg doses, but not the 80-mg dose because of concerns about its risk to the muscles and kidneys. 5 Zetia and Vytorin In 1990, Schering-Plough began to work on acyl CoA cholesterol acyltransferase (ACAT) inhibitors to treat atherosclerosis.

Naproxen is twice as potent as ibuprofen and has a much longer halflife in the body. Under the leadership of Philip Needleman, G. D. Searle came up with the first COX-2 selective inhibitor celecoxib (Celebrex), first synthesized in 1993. 74 Both Celebrex and Vioxx quickly became blockbuster drugs for the treatment of osteoarthritis (OA) and rheumatoid arthritis (RA). But Vioxx was withdrawn from the market in 2004 when it was found that it increased the risk of myocardial infarction and stroke in comparison to naproxen.

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