Download Chemical Mutagens: Environmental Effects on Biological by L Fishbein PDF

By L Fishbein

Chemical Mutagens: Environmental results on organic structures brings jointly appropriate proof approximately man made and of course happening mutagenic chemical compounds.
Organized into components, this publication starts off with an easy dialogue at the smooth techniques of the gene on the molecular and biochemical degrees. the 1st half additionally seems to be into the differing kinds of mutations and the way they shape, in addition to the organic structures used for his or her detection. the second one half bargains with the person chemical mutagens of environmental importance, together with their manufacture, incidence, approach to detection, degradation, and metabolism. It additionally discusses the kinds of mutation chemical mutagens result in within the numerous try platforms which have been applied.
This publication will function unmarried resource fabric for its application to scholars, investigators, and people concerned with public healthiness.

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Chemical Mutagens: Environmental Effects on Biological Systems

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Furthermore, there does not seem to be a correlation between carcinogenic activity and the extent of binding of various polycyclic hydrocarbons to D N A in vitro. The noncarcinogenic pyrene is more readily solubilized by D N A than the potent carcinogen, 3-methylcholanthrene (105). In fact, it is questionable whether the physical interaction of polycyclic hydrocarbons with D N A observed in vitro bears any relationship to the firm binding found in vivo (106). Brookes and Lawley (107) and others (106, 108) have provided evidence indicating that some kind of covalent attachment of hydrocarbons to D N A is effected in vivo and that the nature of the bound product is distinguishable from that of the hydrocarbon itself (109).

On the other hand, this overgrowth could be accomplished in rapidly dividing tissue (where new cells are constantly being regenerated and old cells are dying) should the mutant cell resist death and continue to proliferate as rapidly as do the others of this particular organ. A third mechanism would be provided if the mutant cell secreted a substance which would be inhibiting the growth of surrounding cells but not of itself, as occurs in fact in lower organisms. N o doubt, other mechanisms can be envisaged to account for how a mutant somatic cell might outgrow its normal counterparts and establish itself at their expense but there is little evidence to support any of these ideas.

Evidence for the mutagenicity of aflatoxin has been obtained in plant cells of Vicia faba ( 1 2 9 ) and in human cells grown in tissue culture ( 1 2 9 ) . In b o t h cases, the evidence is based on abnormalities produced in mitotic chromosomes; both chromosomal fragments and bridges were observed. In the mouse, evidence for the mutagenicity of aflatoxin has been provided by the dominant lethal test ( 1 3 0 ) which may be related to the chromosome-breaking effect (see Chap. 5 ) . D. CAFFEINE (1,3,7-TRIMETHYLXANTHINE) 1.

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