By Icon Health Publications
It is a 3-in-1 reference ebook. It supplies a whole clinical dictionary overlaying thousands of phrases and expressions with regards to Chlamydia trachomatis. It additionally offers wide lists of bibliographic citations. ultimately, it offers details to clients on find out how to replace their wisdom utilizing a variety of net assets. The e-book is designed for physicians, clinical scholars getting ready for Board examinations, clinical researchers, and sufferers who are looking to get to grips with study devoted to Chlamydia trachomatis. in case your time is efficacious, this booklet is for you. First, you won't waste time looking the web whereas lacking loads of correct info. moment, the publication additionally saves you time indexing and defining entries. ultimately, you won't waste time and cash printing 1000's of web content.
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Extra info for Chlamydia Trachomatis - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
Women aged 14-29 with documented C. trachomatis cervicitis will be enrolled from family planning services, STD clinics, adolescent clinics and gynecology clinics in Pennsylvania and South Carolina. Baseline characteristics including risk factors for STDs and attitudes about screening will be collected. Women will be randomly assigned in equal numbers to 1) home samplings vs. 2) return visits for screening. At 6, 12, and 18 months, the two groups will then receive either 1) selfsampling vaginal swabs that they can elect to be mailed home or picked-up or 2) postcard reminders to return to the enrollment site for screening.
The first specific aim of this project will be to fully characterize 1- deoxyxylulose-5-phosphate reductoisomerase (DXR), the second enzyme in the pathway and one which has been shown to be inhibited by the known antibacterial agent, fosmidomycin. This aim will be accomplished by 1) Purifying and obtaining kinetic data for the recombinant enzymes from the cyanobacterium Synechocystis sp. PCC6803 and Helicobacter pylori. 2) Examining the stereochemistry of the reduction step by using DXP specifically deuterated at C3 3) Preparing and characterizing eleven site-directed mutants of DXR 4) Synthesizing alternate substrates and proposed inhibitors and assaying for their effects on and 5) Testing in vitro inhibitors for antibacterial activity.
However, the development of host-free (intact chlamydiae isolated from host cells) and in vitro transcription methodologies and the successful DNA sequencing of several chlamydial genomes offers new opportunities to identify regulatory DNA elements and transcriptional regulators that bind to these elements. Host-free and in vitro strategies will be used to accomplish four specific aims. 1. Determine the role of alternative sigma factors in gene expression in Chlamydia trachomatis. The temporal expression and the interaction of the sigma factors and their regulators will be characterized, and the promoters regulated by the sigma factors will be identified.