Download Comparative Biology of the Normal Lung, Second Edition by Richard A. Parent PDF

By Richard A. Parent

Comparative Biology of the traditional Lung, 2d Edition, bargains a rigorous and accomplished reference for all these focused on pulmonary examine. This absolutely up to date paintings is split into sections on anatomy and morphology, body structure, biochemistry, and immunological reaction. It maintains to supply a special comparative viewpoint at the mammalian lung. This variation contains numerous new chapters and increased content material, together with getting older and improvement of the conventional lung, mechanical houses of the lung, genetic polymorphisms, the comparative influence of rigidity of pulmonary immune functionality, oxygen signaling within the mammalian lung and masses extra. via addressing medical advances and important matters in lung examine, this 2d variation is a well timed and important paintings on comparative information for the translation of experiences of animal types compared to the human lung.

  • Edited and authored via specialists within the box to supply an exceptional and well timed assessment of cross-species comparisons that can assist you interpret and evaluate info from animal stories to human findings
  • Incorporates lung anatomy and body structure, mobilephone particular interactions and immunological responses to supply you with a unmarried and specific multidisciplinary resource at the comparative biology of the traditional lung
  • Includes new and accelerated content material on neonatal and elderly lungs, developmental strategies, cellphone signaling, antioxidants, airway cells, safeguard pharmacology and masses extra
  • Section IV on actual and Immunological Defenses has been considerably up-to-date with nine new chapters and an elevated specialize in the pulmonary immunological system

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Example text

1981). Isolated peripheral airways that have less intrinsic airway wall support are more compliant than central airways but derive support in situ from attachments to the surrounding parenchyma. Peripheral airways are, however, more compliant than central airways, particularly at low lung volumes. 6 DIAMETER OF PARENT BRONCHUS (mm) FIGURE 9 The asymmetry of branching of parent airways of different sizes (larger airways correspond to central and smaller to relatively peripheral levels) for data from four different species.

TRACHEA AND AIRWAYS The geometry and stiffness of the trachea and the lobar and segmental bronchi are of interest because these airways contribute a major portion of the overall resistance to 33 34 SECTION | I Structural and Cellular Diversity of the Mammalian Respiratory System Mouse Rat Monkey 1 FIGURE 1 Comparison of mouse, rat, and monkey airways. For the mouse and the rat there are a total of five lobes, one on the left and four on the right. For the nonhuman primate lung there are a total of six lobes, two on the left and four on the right.

This pattern resembles the monopodial branching of pine trees where sprouts appear laterally along preexisting branches. The basis of asymmetric branching is unclear, but the shape of the lung or lobe may contribute; relatively spherical lobes, such as the lower lobes of the human, are relatively symmetric, while long, narrow lobes in small mammals are relatively asymmetric. The asymmetry of airway branching can be assessed by the number of airways in successive orders (the branching ratio), by the relationship between the order of two daughter airways at a bifurcation (delta), or by the distribution of the number of bifurcations between the trachea Architecture of the Tracheobronchial Tree Chapter | 4 43 FIGURE 6 Schematic representation of a relatively symmetrically branching airway system and one that branches asymmetrically.

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