By Anthony P. Pugsley (auth.), Jos A. F. Op den Kamp (eds.)
The assembly on "Dynamics of Membrane Assembly.", subsidized through NATO clinical Affairs department as a sophisticated examine Institute and through FEBS as a Lecture direction was once held in Cargese, France, in June 1991. this system integrated introductory lectures, really good updated contributions and poster classes. Emphasis was once laid at the new advancements within the box of membrane biogenesis, specifically at the biosynthesis of phospholipids and the appliance of contemporary genetic concepts in those experiences; at the membrane insertion and translocation of proteins; on intracellular protein and membrane site visitors; and at the mutual interactions among some of the occasions taking place in the course of membrane biogenesis. a lot development in those learn components has been made lately and the ASI supplied an outstanding chance to demonstrate this development compared to prior conferences on the same subject. not just graduate scholars and postdocs took virtue from this application but in addition skilled scientists got the chance to procure an entire evaluation of contemporary development and the remodelling of rules and concepts.
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Acids Res. (In press). McGraw, P. and S. A. Henry. 1989. Mutations in the Saccharomyces cerevisiae opi3 Gene: Effects on Phospholipid Methylation, Growth and Cross-Pathway Regulation of Inositol synthesis. Genetics, 122: 317-330. Nikoloff, D. M. and S. A. Henry. 1991. Genetic Analysis of Yeast Phospholipid Biosynthesis. In: Ann. Rev. Gen. (In press) . , C. Field and R. Schekman. 1980. Identification of 23 Complementation Groups Required for Posttranslational Events in the Yeast secretory Pathway.
1991]. If PtdCho synthesis is interrupted by a lesion in the de novo biosynthetic pathway, proper regulation of expression of genes encoding lipid synthesizing enzymes in response to soluble lipid precursors is abolished. In these mutants addition of soluble lipid precursors entering the PtdCho biosynthetic cascade beyond the metabolic lesion ~a the "Kennedy"-pathway may restore synthesis of PtdCho and the regulatory signal. §] ~ inositol ext. - G-6-P #t inol m~t~ I-I-P ~ i --+ --+~ tt cpt ~cct t tt cki ~ ctr ~ctr ethanolamineext.
Cell, 64: 789-800. Culbertson, M. R. and S. A. Henry. 1975. Inositol Requiring Mutants of Saccharomyces cerevisiae. Genetics, 80: 23-40. Culbertson, M. , T. F. Donahue and S. A. Henry. 1976. Control of Inositol Biosynthesis in Saccharomyces cerevisiae. I. Properties of a Repressible Enzyme System in Extracts of Wildtype (ino+) Cells. J. , 126: 232-242. Donahue, T. F. and S. A. Henry. 1981. Myoinositol-lPhosphate Synthetase: Characteristics of the Enzyme and Identification of its Structural Gene in Yeast.