By Federico Cappuzzo
Guide to specific cures: EGFR Mutations in NSCLC is a fast and up to date assessment, which discusses EGFR mutations, trying out equipment and know-how, present and rising treatments, and assets that clinicians offers to their sufferers. Busy healthcare pros who need a fast assessment of EGFR gene mutations in addition to a precis of present treatments will reap the benefits of this succinct guide.
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Additional resources for Guide to Targeted Therapies: EGFR mutations in NSCLC
Douillard JY, Shepherd FA, Hirsh V, et al. Molecular predictors of outcome with gefitinib and docetaxel in previously treated non-small-cell lung cancer: data from the randomized phase III INTEREST trial. J Clin Oncol. 2010;28:744-752. Takano T, Fukui T, Ohe Y, et al. EGFR mutations predict survival benefit from gefitinib in patients with advanced lung adenocarcinoma: a historical comparison of patients treated before and after gefitinib approval in Japan. J Clin Oncol. 2008;26:5589-5595. Oxnard GR, Arcila ME, Sima CS, et al.
Overall, available data have demonstrated that erlotinib is superior to platinum-based chemotherapy in patients with EGFR mutations. Although no study has demonstrated a survival difference, probably because of the confounding effect of post-study treatments, the superiority in terms of response rate, progression-free survival, quality of life, and toxicity strongly support erlotinib in first-line setting in EGFR-selected patients with NSCLC. E G FR -ta r g e t e d t h e r a p i e s i n n o n -s mall c e ll lu n g ca n c e r • 49 Studies with afatinib The role of the irreversible EGFR-TKI afatinib in the first-line setting in patients harboring EGFR mutations has been investigated in three studies.
The survival results observed in the FLEX and BMS099 trials clearly indicated that there is a consistent fraction of patients with NSCLC deriving no or little benefit from cetuximab therapy, thus highlighting the importance of proper patient selection. 1. Data in colorectal cancer (CRC) showed that increased EGFR gene copy number as detected by fluorescence in situ hybridization (FISH) might be associated with increased sensitivity to cetuximab, at least in terms of response and time to progression (TTP) [12,13].