By K. C. Nicolaou, Rudolf Hanko, Wolfgang Hartwig
In the end, the mechanism-based and application-oriented guide of combinatorial chemistry.Since its very starting, study during this box has endured to enhance at a swift price. more and more dependent tools are being invented and a fair wider diversity of attainable purposes remains to be being found, such that combinatorial chemistry is now an essential component of commercial and educational research.The high-class editorial workforce - ok. C. Nicolaou of The Scripps Institute and UCSD, and R. Hanko and W. Hartwig from Bayer - confirm finished assurance and first class contributions. This two-volume paintings offers with man made chemistry in all its varieties, functions from existence sciences, chemistry andmaterial sciences, all there's to grasp approximately compound library layout and synthesis, and, after all, the overall fundamentals - making it an quintessential reference for artificial, natural and medicinal chemists, chemical biologists in addition to fabric scientists.
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Additional resources for Handbook of Combinatorial Chemistry: Drugs, Catalysts, Materials (2-Vol. Set)
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G. polystyrene-bound isocyanates which react selectively with primary and secondary amines. Thus excess reagents are ﬁrst used to drive reactions to completion. Subsequently, scavenger resins are added to the reaction mixture. After selective coupling of the resin to the excess starting material the insoluble material is removed by ﬁltration and the product remains in pure form (Fig. 6). Also the second approach to simplify solution-phase chemistry relies on the separation of insoluble material from the reaction mixture and combines the beneﬁts of solid- and solution-phase chemistry (Fig.