By Victor R Preedy (ed.)
Carnosine and anserine are universal histidine-derived dipeptides, sometimes called imidazole dipeptides, present in muscle and mind tissues of animals. Their nutritional and dietary value lies of their antioxidant homes and a couple of investigators are taking a look at different well-being advantages of the compounds.
This quantity surveys the present kingdom of play in those and different components of curiosity, together with chemistry and biochemistry, immunology and mobile homeostasis. Chapters glance extensive at the various services and results within the physique fairly in regards to workout and fatigue, wound therapeutic, melanoma therapy and age-related ailments. delivering an up to the moment, interdisciplinary procedure, this publication is of serious curiosity to researchers and execs in chemistry, meals technology, food, biochemistry, future health sciences and activities sciences.
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Extra info for Imidazole dipeptides : chemistry, analysis, function and effects
Park, G. , Barry, A. , Blackburn, N. J. and Karlin, K. , 2007. Synthesis and X-ray absorption spectroscopy structural studies of Cu(i) complexes of histidylhistidine peptides: the predominance of linear 2-coordinate geometry. Journal of the American Chemical Society. 129: 5352–5353. Kavanagh, K. , 2004. Histatins: antimicrobial peptides with therapeutic potential. Journal of Pharmacy and Pharmacology. 56: 285–289. , Baidya, M. , 2012. Kinetics and mechanism of organocatalytic aza-Michael additions: direct observation of enamine intermediates.
J. and Karlin, K. , 2007. Synthesis and X-ray absorption spectroscopy structural studies of Cu(i) complexes of histidylhistidine peptides: the predominance of linear 2-coordinate geometry. Journal of the American Chemical Society. 129: 5352–5353. Kavanagh, K. , 2004. Histatins: antimicrobial peptides with therapeutic potential. Journal of Pharmacy and Pharmacology. 56: 285–289. , Baidya, M. , 2012. Kinetics and mechanism of organocatalytic aza-Michael additions: direct observation of enamine intermediates.
It is worth noting the key interactions stabilized by the zinc ions with both the carboxylate and the carbonyl group, the ammonium interacts with Asp116 and Glu451, while the imidazole ring elicits H-bonds with Leu254 and Thr424. The figure is reprinted from Vistoli et al. (2006) with kind permission from ACS. 4 Main interactions stabilizing the putative complex between carnosine and human peptide transporter hPepT1. One may note the interactions stabilized by the ammonium head that involve a strong H-bond with Tyr588 plus ion pairs with Glu23 and Glu26.