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By Wilfried M.A. Niessen

"...Discusses how the strategy works and the way to interpret effects. ...Describes the effect of [LC-MS] on small-molecule and biomolecular applications...- Biophotonics overseas, August 2006Featuring new chapters and broad revisions during the booklet, this booklet explains tips to use LC-MS and interpret info for varied disciplines. putting a higher emphasis on purposes than past variations, this variation additionally dedicates greater than two-thirds of the textual content to analyzing new advancements of LC-MS in rising program parts, together with environmental, food-safety, and medical research in addition to proteomics, pharmaceutical drug discovery and ordinary items learn. every one bankruptcy examines how contemporary advances suggestions, and applied sciences formed each one of those disciplines, supported through such a lot correct literature on hand.

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45 1. Introduction Mass spectrometry (MS) is based on the production of ions, that are subsequently separated or filtered according to their mass-to-charge (m/z) ratio and detected. The resulting mass spectrum is a plot of the (relative) abundance of the generated ions as a function of the m/z. Excellent selectivity can be obtained, which is of utmost importance in quantitative trace analysis. This chapter is not a brief introduction in MS, but rather highlights important aspects for the discussions on liquid chromatography–mass spectrometry (LC–MS) to come.

Acta, 402 (1999) 1. 11. K. Albert, LC–NMR spectroscopy, J. Chromatogr. A, 856 (1999) 199. 12. M. Montes-Bayón, K. A. Caruso, LC–ICP-MS, J. Chromatogr. A, 1000 (2003) 457. 13. B. P. E. Regnier, Perfusion chromatography packing materials for proteins and peptides, J. A, 544 (1991) 267. 14. M. Rhemrev-Boom, M. Yates, M. Rudolph, M. Raedts, (I)AC: a versatile tool for fast and selective purification, concentration, isolation and analysis, J. Pharm. Biomed. , 24 (2001) 825. 15. -C. Hennion, V. Pichon, Immuno-based sample preparation for trace analysis, J.

Ultramark 1621, a mixture of fluorinated phosphazenes, was proposed as a reference compound for calibration in the range of m/z 800 to 2000 [28]. It was also recommended for ion-trap instruments from Thermo Finnigan. Ultramark 1621 strongly adsorbs to surfaces and is difficult to remove due to its poor solubility in common solvents [30]. A proprietary mixture of fluorinated phosphazenes is recommended as reference compound by Agilent Technologies. Water cluster ions have been proposed for calibration up to m/z 3000 [31].

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