Download Lupus - A Medical Dictionary, Bibliography, and Annotated by Icon Health Publications PDF

By Icon Health Publications

This can be a 3-in-1 reference booklet. It offers an entire clinical dictionary overlaying thousands of phrases and expressions in terms of lupus. It additionally offers large lists of bibliographic citations. eventually, it presents info to clients on tips on how to replace their wisdom utilizing a number of web assets. The publication is designed for physicians, clinical scholars getting ready for Board examinations, scientific researchers, and sufferers who are looking to familiarize yourself with study devoted to lupus. in case your time is effective, this publication is for you. First, you won't waste time looking out the web whereas lacking loads of suitable info. moment, the publication additionally saves you time indexing and defining entries. eventually, you won't waste time and cash printing countless numbers of web content.

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Extra resources for Lupus - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References

Sample text

Since there has long been suggestive evidence for a role of E2 in SLE, they have been studying the impact of E2 treatment on B cell tolerance. Examination of non autoimmunity mice that are transgenic for the heavy chain of a pathogenic anti DNA antibody revealed that a sustained increase in E2 disrupts normal B cell tolerance of anti DNA B cells and leads to an increase in anti DNA antibody titers, an expansion of anti DNA B cells and glomerular immunoglobulin deposition. The autoimmune phenotype observed in E2 treated mice is characterized by the altered distribution of splenic B cell subsets, with a diminished immature transitional population and an increase in marginal zone B cells.

In both models, this interaction is theorized to help activate the marginal zone B cells to secrete autoantibodies, such as anti-dsDNA antibodies, of the pathogenic IgG2a isotype. In vivo and in vitro experiments focus on purifying NK T cells, and on purifying the marginal zone B cells with appropriate mAbs by flow cytometry. We have recently shown that the marginal zone B cells from NZB/NZW mice are the only subset that spontaneously secretes IgM autoantibodies, and is also expressing the IgG2a constant region gene.

By implanting these cells under the renal capsule we have created a system to introduce the continuing presence of CSF-1 (or other cytokines) into the kidney. We can then establish if CSF-1 recruits macrophages and determine whether CSF-1 will induce or accelerate renal injury in the MRL-++, C3H-lpr/lpr strains. To definitely establish whether CSF-1 or other cytokines have an enhanced glomerular expression prior to the influx of macrophages, we will isolate and pool individual glomeruli (glom) from MRL-lpr/lpr, congenic, and normal mice at varying ages and quantitate the level of cytokine and macrophages specific marker mRNA using the competitive template polymerase chain reaction.

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