By Donald E.Wesson
This well timed quantity offers an outline to the factors, results on structures and medical ways of metabolic acidosis. starting with a uncomplicated knowing of the body structure, pathophysiology and improvement of this disorder, next chapters hide the features and context of the techniques which can reason it and an intensive presentation of administration suggestions. steered remedies comprise these conducted through the health practitioner in addition to the person sufferer, corresponding to nutritional administration. Clinicians and healthcare pros will locate the instruments had to realize, paintings up and deal with sufferers with metabolic acidosis during this useful and concise resource.
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Extra info for Metabolic Acidosis: A Guide to Clinical Assessment and Management
Paradoxically, bicarbonate therapy activates phosphofructokinase, which is regulated by intracellular pH, thereby increasing lactate production. For all of these reasons, NaHCO3 should be used cautiously with the goal of increasing the plasma [HCO3−] to no more than 5–8 mmol/L. If the underlying cause of the l-lactic acidosis can be remedied, blood lactate will be reconverted to HCO3−. The bicarbonate derived metabolically from lactate conversion is additive to any new HCO3− generated by kidney mechanisms during acidosis and from exogenous alkali therapy might lead to an “overshoot” alkalosis.
2003;22:129–36. Fomepizole for ethylene glycol and methanol poisoning. N Engl J Med. 2009;360:2216–23. Clinical toxicologic implications of ethylene glycol and glycolic acid poisoning. Ther Drug Monit. 2002;24:232–8. 22. Ethylene glycol ingestion treated only with fomepizole. J Med Toxicol. 2007;3:125–8. 23. Unexplained metabolic acidosis in critically ill patients: the role of pyroglutamic acid. Intensive Care Med. 2004;30:502–5. Propylene glycol toxicity in a patient receiving intravenous diazepam.
In: DuBose TD, Hamm LL, editors. Acid–base and electrolyte disorders: a companion to Brenner and Rector’s the kidney. Philadelphia: Saunders; 2002. 165–87. Ketoacidosis. In: DuBose TD, Hamm LL, editors. Acid–base and electrolyte disorders: a companion to Brenner and Rector’s the kidney. Philadelphia: Saunders; 2002. 67–82. 17. Umpierrez GE, DiGirolamo M, Tuvlin JA, et al. Differences in metabolic and hormonal milieu in diabetic- and alcohol-induced ketoacidosis. J Crit Care. 2000;15:52–9. Renal tubular acidosis.