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By Philip M Farrell (Eds.)

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20. Lauweryns, J. , and Baert, J. H. (1977). Alveolar clearance and the role of the pulmonary lymphatics. Am. Rev. Respir. Dis 115, 625-683. 21. Macklin, C. C. (1954). The pulmonary alveolar mucoid film and the pneumonocytes. Lancet 1, 1099-1104. 22. , and Turner, J. (1964). Topography of esophageal pressure as a function of posture in man. J. Appl. Physiol. 19, 212-219. 23. , and Permutt, S. (1981). Effect of ventilation on the surface properties of the lung. 2. Clinical Relevance of Pulmonary Surfactant 24.

Such 23 Lung Development: Biological and Clinical Perspectives, Vol. II Copyright © 1982 by Academic Press, Inc. All rights of reproduction in any form reserved. ISBN 0 - 1 2 - 2 4 9 7 0 2 - 3 24 I. Clinical Aspects of HyaUne Membrane Disease methods of treatment are designed to facihtate spontaneous *'natural recovery" from the disease after 3-4 days of illness (25). Because of the intensity of care required for HMD, this disorder is largely responsible for the development and proliferation of newborn critical care units in recent years.

Thus, maximal lung volume, at which the terminal air spaces are filled but not overstretched, was significantly increased by corticosteroid administration to rabbit fetuses. For adequate functioning, immature lungs must not only have 2. Clinical Relevance of Pulmonary Surfactant 17 their surface tension management system induced, but must also undergo suffi­ cient moφhological development (18). Static pressure-volume studies at different temperatures have revealed that either large tidal volumes or small end tidal lung volumes may increase surfactant turnover (9) (see Chapter 4, Vol.

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